Suggested immobilization test for diagnosis of restless legs syndrome in Parkinson's disease.
Identifieur interne : 000089 ( France/Analysis ); précédent : 000088; suivant : 000090Suggested immobilization test for diagnosis of restless legs syndrome in Parkinson's disease.
Auteurs : Valérie Cochen De Cock [France] ; Sophie Bayard ; Huan Yu ; Magda Grini ; Bertrand Carlander ; Ron Postuma ; Mahmoud Charif ; Yves DauvilliersSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease, Restless Legs Syndrome.
- diagnosis : Restless Legs Syndrome.
- methods : Immobilization.
- physiology : Sleep.
- physiopathology : Parkinson Disease, Restless Legs Syndrome.
- Aged, Female, Humans, Male, Middle Aged, Polysomnography.
Abstract
Diagnosis of restless leg syndrome (RLS) in Parkinson's disease (PD) is difficult because of clinical confounds. The suggested immobilization test (SIT) is validated for diagnosis of primary RLS. This study evaluated the usefulness of the SIT for diagnosis of RLS in PD. We compared SIT scores, as well as polysomnography measures in 50 patients with PD (25 with RLS, 25 without), 25 patients with primary RLS, and 25 age/sex matched controls. Mean leg discomfort score was increased in patients with PD and RLS compared to PD without RLS, and also in patients with primary RLS compared to controls. Leg discomfort was significantly higher at the end of the test in patients with RLS compared to patients without RLS. Intensity of leg discomfort was similar between patients with RLS, with or without PD. Using a mean leg discomfort cutoff of 11, we showed sensitivity of 91% and specificity of 72% for RLS diagnosis in PD during symptomatic time intervals. Periodic leg movements index during the SIT did not differ between groups. Periodic leg movements index during sleep and wakefulness was increased in patients with primary RLS compared to controls, but did not differ between patients with PD, with and without RLS. The sensory SIT is a simple test that may help diagnose RLS in patients with PD.
DOI: 10.1002/mds.24969
PubMed: 22437899
Affiliations:
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pubmed:22437899Le document en format XML
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Yu</name></author><author><name sortKey="Grini, Magda" sort="Grini, Magda" uniqKey="Grini M" first="Magda" last="Grini">Magda Grini</name></author><author><name sortKey="Carlander, Bertrand" sort="Carlander, Bertrand" uniqKey="Carlander B" first="Bertrand" last="Carlander">Bertrand Carlander</name></author><author><name sortKey="Postuma, Ron" sort="Postuma, Ron" uniqKey="Postuma R" first="Ron" last="Postuma">Ron Postuma</name></author><author><name sortKey="Charif, Mahmoud" sort="Charif, Mahmoud" uniqKey="Charif M" first="Mahmoud" last="Charif">Mahmoud Charif</name></author><author><name sortKey="Dauvilliers, Yves" sort="Dauvilliers, Yves" uniqKey="Dauvilliers Y" first="Yves" last="Dauvilliers">Yves Dauvilliers</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.24969</idno><idno type="RBID">pubmed:22437899</idno><idno type="pmid">22437899</idno><idno 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France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité des troubles du sommeil, Service de Neurologie, Hôpital Gui de Chauliac, Montpellier</wicri:regionArea><placeName><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Bayard, Sophie" sort="Bayard, Sophie" uniqKey="Bayard S" first="Sophie" last="Bayard">Sophie Bayard</name></author><author><name sortKey="Yu, Huan" sort="Yu, Huan" uniqKey="Yu H" first="Huan" last="Yu">Huan Yu</name></author><author><name sortKey="Grini, Magda" sort="Grini, Magda" uniqKey="Grini M" first="Magda" last="Grini">Magda Grini</name></author><author><name sortKey="Carlander, Bertrand" sort="Carlander, Bertrand" uniqKey="Carlander B" first="Bertrand" last="Carlander">Bertrand Carlander</name></author><author><name sortKey="Postuma, Ron" sort="Postuma, Ron" uniqKey="Postuma R" first="Ron" last="Postuma">Ron Postuma</name></author><author><name sortKey="Charif, Mahmoud" sort="Charif, Mahmoud" uniqKey="Charif M" first="Mahmoud" last="Charif">Mahmoud Charif</name></author><author><name sortKey="Dauvilliers, Yves" sort="Dauvilliers, Yves" uniqKey="Dauvilliers Y" first="Yves" last="Dauvilliers">Yves Dauvilliers</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Immobilization (methods)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (physiopathology)</term><term>Polysomnography</term><term>Restless Legs Syndrome (complications)</term><term>Restless Legs Syndrome (diagnosis)</term><term>Restless Legs Syndrome (physiopathology)</term><term>Sleep (physiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immobilization</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Sleep</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polysomnography</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Diagnosis of restless leg syndrome (RLS) in Parkinson's disease (PD) is difficult because of clinical confounds. The suggested immobilization test (SIT) is validated for diagnosis of primary RLS. This study evaluated the usefulness of the SIT for diagnosis of RLS in PD. We compared SIT scores, as well as polysomnography measures in 50 patients with PD (25 with RLS, 25 without), 25 patients with primary RLS, and 25 age/sex matched controls. Mean leg discomfort score was increased in patients with PD and RLS compared to PD without RLS, and also in patients with primary RLS compared to controls. Leg discomfort was significantly higher at the end of the test in patients with RLS compared to patients without RLS. Intensity of leg discomfort was similar between patients with RLS, with or without PD. Using a mean leg discomfort cutoff of 11, we showed sensitivity of 91% and specificity of 72% for RLS diagnosis in PD during symptomatic time intervals. Periodic leg movements index during the SIT did not differ between groups. Periodic leg movements index during sleep and wakefulness was increased in patients with primary RLS compared to controls, but did not differ between patients with PD, with and without RLS. The sensory SIT is a simple test that may help diagnose RLS in patients with PD.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Montpellier</li></settlement></list><tree><noCountry><name sortKey="Bayard, Sophie" sort="Bayard, Sophie" uniqKey="Bayard S" first="Sophie" last="Bayard">Sophie Bayard</name><name sortKey="Carlander, Bertrand" sort="Carlander, Bertrand" uniqKey="Carlander B" first="Bertrand" last="Carlander">Bertrand Carlander</name><name sortKey="Charif, Mahmoud" sort="Charif, Mahmoud" uniqKey="Charif M" first="Mahmoud" last="Charif">Mahmoud Charif</name><name sortKey="Dauvilliers, Yves" sort="Dauvilliers, Yves" uniqKey="Dauvilliers Y" first="Yves" last="Dauvilliers">Yves Dauvilliers</name><name sortKey="Grini, Magda" sort="Grini, Magda" uniqKey="Grini M" first="Magda" last="Grini">Magda Grini</name><name sortKey="Postuma, Ron" sort="Postuma, Ron" uniqKey="Postuma R" first="Ron" last="Postuma">Ron Postuma</name><name sortKey="Yu, Huan" sort="Yu, Huan" uniqKey="Yu H" first="Huan" last="Yu">Huan Yu</name></noCountry><country name="France"><noRegion><name sortKey="De Cock, Valerie Cochen" sort="De Cock, Valerie Cochen" uniqKey="De Cock V" first="Valérie Cochen" last="De Cock">Valérie Cochen De Cock</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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